FPI fellowship Magnesiums Signaling

CIC bioGUNE announces a FPI fellowship associated Proyectos de 
Generación de Conocimiento 2024 for a PhD thesis at Dr. Malu Martinez Chantars Liver 
Disease Lab at CIC bioGUNE, Vizcaya. The project, titled "Exploring Magnesiums 
Signaling Role in Type 2 Diabetes and Aging: Transformative Perspectives in 
Magnesium Research (MAGNIT2D)", offers a unique opportunity to delve into 
groundbreaking research on magnesiums role in metabolic health and disease.

Project Overview: Despite the well-known effects of intracellular Mg2+ 
concentrations, the intricate regulation of these concentrations by ion channels and 
transporters remains poorly understood. This project aims to illuminate the role 
of Mg2+ transporters, which exhibit significant dysregulation in metabolically 
compromised organs, in the development of Mg2+-related disturbances associated 
with "inflammaging" and Type 2 Diabetes (T2D), including mitochondrial dysfunction, 
genomic instability, and reactive oxygen species production. Specifically, our 
objective is to unravel the systemic regulation of this essential "messenger 
cation" in metabolically compromised tissues such as the liver, adipose tissue, 
pancreas, and brain. By delving into this investigation, we aspire to enhance our 
understanding of the impact of Mg2+ and Mg2+ transporters on the onset and 
progression of T2D.

The start date for this fellowship is between December 2024 and January 
2025.