The candidate should have a PhD in structural biology or membrane protein
biochemistry, and have a background in protein purification and structural biology (
ideally cryo-electron microscopy) with a solid publication record. The candidate
will apply structural biology, cell biology, biophysics and in silico protein
design to understand orphan GPCRs and develop new drugs (Arroyo-Urea et
al-Preprint ResearchSquare-2023, Gusach-Curr Opi Struc Biol-2023, Lee-Nature-2020,
García-Nafria-Nature-2018). The project is fully funded and will involve
collaborating with a pharmaceutical company located in Cambridge, UK. The post has a
duration of 2 years with a possibility of extension. Candidates with a strong
publication record willing to learn structural biology are also encouraged to apply and
assess feasibility to apply for additional fellowships such as Juan de La Cierva.
The group is found at the BIFI Institute (U. of Zaragoza) and it is
state-of-the-art equipped for protein production in bacterial, insect and mammalian
organisms, tissue culture, biophysics (ITC, Thermophoresis, DSC, light scattering,
single-molecule fluorescence) and structural biology. The group is part of the
Laboratory of Advanced Microscopies (LMA) within the same building, with TEM
microscopes T20 and F30, Vitrobot, glow discharge and plasma cleaner for cryo-EM sample
preparation. The Institute is also part of the Spanish Supercomputing Network
and has a computer cluster for data processing.
